Showing posts with label Technology. Show all posts
Showing posts with label Technology. Show all posts

Wednesday, June 09, 2021

Experts vs. Dart-Throwing Monkeys

 


Statistics was never one of my favourite subjects. When faced with grades at the wrong end of the bell-curve, I would console myself with a quote attributed to Mark Twain - "There is lies, damn lies, and statistics"!

However, over the years, I have warmed-up to the subject - thanks largely to the stunning visualisations of Hans Rosling, and books like Daniel Kahneman's "Thinking Fast, Thinking Slow". This post is about the latter. 

The nudge for this came about ten days ago when a friend posted a book recommendation with a quote by Richard Feynman - "The first rule in science is that you must not fool yourself, and you are the easiest person to fool". The book in question was - "The power and paradox of self-deception" by Shankar Vedantam.

The first question that came to my mind was - Is this any different from the ideas described so well in Kahneman's book?  I went back to the book and found that he discussed not only all sorts of cognitive biases but also ways in which the intuitions of subject experts can be built into robust decision-making models.

What I like about Kahneman is that he is a practitioner who moved to academia. Unlike most ivory tower theorists, he served in the fledgeling Israeli Army in the 1950s, setting SoPs (still in use) for officer selection before moving to a university in USA, and winning the first Nobel prize for psychology/economics in 2002. 

Two of my key takeaways from this book were on Subjective Confidence and Intuitions vs. Formulas. Here are two quotes from the book on the topics which are perhaps best described in the author's own words. 

First, Subjective Confidence.

Facts that challenge...basic assumptions - and thereby threaten people's livelihood and self esteem - are simply not absorbed. The mind does not digest them. This is particularly true of statistical studies of performance, which provide base rate information that people generally ignore when it clashes with their personal impressions

We know that people can maintain an unshakable faith in any proposition, however absurd, when they are sustained by a community of like-minded believers

In other words, people who spend their time, and earn their living, studying a particular topic produce poorer predictions than dart-throwing monkeys who would have distributed their choices evenly over the options. Even in the region they knew best, experts were not significantly better than non-specialists...The reason is that a person who acquired more knowledge develops an enhanced illusion of her skill and becomes unrealistically overconfident. 

...Using an analogy from Isaish Berlin's essay on Tolstoy, "The Hedgehog and the Fox" -

Hedgehogs "know one big thing" and have a theory about the world; they account for particular events within a coherent framework, bristle with impatience towards those who do not see things their way, and are confident about their forecasts. They are also especially reluctant to admit error. For hedgehogs, a failed prediction is almost always "off only on timing", or "very nearly right". They are opinionated and clear, which is exactly what televisions producers like to see on their programs. Two hedgehogs on different sides of an issue, each attacking the idiotic ideas of the adversary, make a good show.

Foxes, on the other hand, are complex thinkers. They don't believe that one big thing drives the march of history. Instead the foxes recognise that reality emerges from the interactions of many different agents and forces, including blind luck, often producing large and unpredictable outcomes....Foxes are less likely to to be invited to participate in television debates.

On Intuitions vs. Formulas

Paul Meehl's book - "Clinical vs. Statistical prediction: A Theoretical Analysis and a Review of Evidence"...This 'disturbing little book' presented the results of 20 studies to examine whether Clinical Predictions based on the subjective impressions of trained professionals were more accurate than statistical predictions made by combining a few scores or ratings according to a rule... The formula was more accurate than 11 or 14 counsellors! It was proven again in other studies on violations of payroll, success in pilot training and criminal recidivism.

Princetown economist and wine lover Orley Ashenfelter shows us the compelling power of the power of simple statistics to outdo world renowned experts. Ashenfelter predicted the future value of Bordeaux wines based on info available the year they were made - he converted conventional knowledge into a statistical formula that predicts the price of wine based on three features of the weather - average temp over the summer growing months, the amount of rain at harvest, and the total rainfall during the previous winter.

A key conclusion... to maximise predictive accuracy, final decisions should be left to formulas, especially in low-validity environments

Does Vedanam's new book present any new ideas? I don't know yet. It does seem to me that path-breaking ideas presented in "Thinking Fast, Thinking Slow" may now be getting repackaged in newer books. Perhaps I am suffering from an anchoring bias, but I do believe Kahneman's book is something you need to have on your nearest bookshelf, as a constant reminder that there is more to this world than meets the eye, that intuitions can be trusted - but only to a certain extent. 

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REFERENCES & LINKS

* Cognitive Biases - https://www.verywellmind.com/what-is-a-cognitive-bias-2794963

* Animated book summary - https://youtu.be/uqXVAo7dVRU

* The hedgehog and the fox - http://assets.press.princeton.edu/chapters/s9981.pdf

* How Big Data can predict the wine of the century - https://www.forbes.com/sites/sap/2014/04/30/how-big-data-can-predict-the-wine-of-the-century/?sh=5f2c35c531a9

Monday, July 13, 2020

Swartz and the Free Internet



Until today I had not heard of the name Aaron Swartz. A dive down one twitter rabbit-hole led me to this documentary and I was quite amazed to learn about this child prodigy, this teenager who was one of the founders of Reddit, an architect of Creative Commons, the slayer of draconian legislations that restricted internet freedom, and conscientious young man who was driven to kill himself by MIT and the Obama administration. 

As if all these were not achievements enough for a lifetime, Swartz also gets the credit to enabling the discovery of a test that leads to the early detection of pancreatic cancer!

A friend who studied at MIT thought there was nothing new or shocking about MITs role in making a scapegoat out of Swartz. "It is difficult to admire MIT if you're a thinking person", he said, "Most of the research there is centred on war weapons and the best way to kill". So it may not be surprising that the Obama government wanted to make an example of a man whose principal crime was to get past the JSTOR paywall and download years of public-funded research papers.

Until last year I would have thought such a move went against the very grain of USAs self-proclaimed   position as a 'land of the free'. The aggressive rise of China, the Covid-19 pandemic, Galwan, and the nine-dash-line leads me to a more hardline position against authoritarian regimes who are trying to turn this freedom into some kind of liability.

If internet freedom and free access of research from US universities only leads to a one-way flow of information and technology, it may not be a bad idea to temper the zeal of youngsters, who, for all their deep knowledge, are unable to see the big picture of global geo-politics.


Friday, June 23, 2017

An Award Ignored

Strange are the ways of the Indian media.

A few days ago, an Indian scientist-entrepreneur based in Japan won the country's top environment award for 2017, and it was barely mentioned here. Bits of the news appeared on the web-editions of India Today and DNA, both apparently sourced from a newsfeed site called UNIIndia.

Dr. Shrihari Chandraghatgi, CEO of EcoCycle Corporation, was awarded the Environment Award for 2017 in Japan for "developing cutting edge technologies to address burning environmental problems". This award is the highest honour given every year jointly by the Ministry of Environment, Japan, National Institute for Environmental Studies (NIES), Japan and The Nikkan Kogyo Shinbun (a media group). What is more,  Chandraghatgi is the first foreigner to win this award.



What exactly is the cutting edge technology developed by Chandraghatgi to address 'burning environmental problems"? According to information available at his company website, EcoCycle has developed a unique technology for environmental remediation and recycling of organic solvents in semiconductor industries. It uses microorganisims to clean the soil and groundwater contaminated with chlorinated solvents and hexavalent chromium. The company has also developed unique on-site emission analytical techniques for semiconductor industries.

India does not have a significant semiconductor industry. Much of its requirements are imported. While this may have been a reason for the rather tepid response here, it fails to see the larger picture. In one of the interviews, Chandraghatgi gives an open offer aimed at India - "Now it is my turn to work in India where large scale health problems are reported because of consuming toxic groundwater. If any organization, government or NGO, wants to take up such cause with concern of public health, I am ready to provide my technology and vast experience free!"

Will this offer be taken up in right earnest? Or will we continue to wear our blinkers and look-up towards the West - USA, Europe - technological breakthroughs that are relevant to India?

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REFERENCES & LINKS

* (20Jun17) -UNI - "Agri. Microbiologist Dr Shrihari Chandraghatgi gets Japan Award" http://www.uniindia.com/agri-microbiologist-dr-shrihari-chandraghatgi-gets-japan-award/states/news/906665.html
- Dr Shrihari is currently helping Ministry of Industry, Thailand in forming environmental regulations and educate with remedial technologies.
- In 2017 he established a NGO, Kibono Hikari literally means Ray of Hope to help under privileged children in India with educational and medical support.

* (21Jun17) - IndiaToday - "Indian Agri-Microbiologist given Environment Award in Japan" - http://indiatoday.intoday.in/story/indian-agri-microbiologist-given-environment-award-in-japan/1/983894.html

* (21Jun17) - DNA - http://www.dnaindia.com/india/report-indian-agri-microbiologist-given-environment-award-in-japan-2479336

* (2015) - Son's donation for Scoriosis treatment - http://bangaloremirror.indiatimes.com/bangalore/others/baby-anjummehboob-patel-shrihari/articleshow/47062930.cms?

* EcoCycle Corporation, Japanhttp://www.ecocycle.co.jp/e_organization/e_organization.html




Friday, June 02, 2017

Microwave Ovens and WiFi Routers




I never cease to wonder about the electromagnetic spectrum. Much of it is invisible to our senses, and yet, we have reached a stage when it is quite impossible to survive without it.

The microwave oven in out kitchens sends out waves at around 2.45 GHz (2,450,000,000,000 vibrations/second!), heating up food at the molecular level. The ubiquitous WiFi that keeps us connected to the internet - and the rest of the world - are "harmonized" worldwide in the 2.4 and 5GHz bands. Even without getting into the world of electronic waves that send signals across great distances (radio, satellite and space probes), getting a grip on regular household devices seems complicated enough!

Both the equipment's - the microwave oven and the WFi router - produce signals in the Industrial, Scientific and Medical (ISM) bands that have been allotted by ITU for non-communication purposes. There seem to be 12 frequency ranges in the ISM band that ranges all the way from 6.78 MHz to 245 GHz. Out of this, home equipment like ovens and WiFi routers use the frequency range 2.45-2.5 GHz.

Since a licence is not required for equipment produced in this range, the part of the spectrum is also crowded with radio-communication services, including amateur satellite services. Thanks to this dual-use, the WiFi equipment you purchase from one country country is likely to interfere with the microwave oven imported from another country. So, if you are heating a mug of coffee in your microwave oven, your internet connection may get disrupted.

International standards - especially IEEE 802.11 a/b/g/n - tries to deal with this problem:
  • 802.11a supports bandwidth up to 54 Mbps and signals in a regulated frequency spectrum around 5 GHz. More expensive, usually used by businesses. Higher frequency makes it difficult to penetrate walls, so its best for open areas.
  • 802.11b supports bandwidth up to 11 Mbps, comparable to traditional Ethernet. Usually for home networks.
  • 802.11g supports bandwidth up to 54 Mbps; uses the 2.4 GHz frequency for greater range
  • 802.11n is an improvement on 802.11g in the amount of bandwidth supported by utilizing multiple wireless signals and antennas (called MIMO technology) instead of one.

It is still mind boggling to think that we have actually figured out ways to precisely control devices that produce more than a trillion vibrations per second! How do we do it? And why is it that microwave ovens need chunky magnetrons to produce the same kind of signals that are produced by lightweight WiFi routers?

In an emergency, can I rig up my WiFi router to heat up a mug of coffee? :)

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LINKS

ITU - http://www.itu.int/en/Pages/default.aspx
http://www.itu.int/itu-t/recommendations/rec.aspx?

https://www.howtogeek.com/171869/why-does-running-my-microwave-kill-my-wi-fi-connectivity/

Wireless Standards - https://www.lifewire.com/wireless-standards-802-11a-802-11b-g-n-and-802-11ac-816553

Thursday, September 15, 2016

Don on Blockchain



Digital currency, Blockchain, Bitcoin...for quite some time now, these terms have been floating around in my mind like dragonflies on a sunny afternoon. I've always wanted to learn more about them but have never got hold of anything that I could relate to - until today.

This TED video by Don Tapscot has finally presented the topic in a way I could finally understand,at least to some extent. One example that struck me in particular was that of Analie Domingo, a Filipino housekeeper living in Toronto. It seems she is now able to send money to her ageing mother in Manila, on a Blockchain app called "Abra". It costs her a  fraction of time and money she used to spend on Western Union money transfers.

I did not know that the biggest flow of funds from the developed world to the developing world is remittances. At USD 600 billion per year, it is a far greater flow of funds than corporate investment or foreign aid. According to Don, it is also the biggest global rip-off by companies like Western Union.

If Blockchain is the wonder technology that can make international money transfers more efficient, if it can help artists earn a fair price for their creations and help maintain digital privacy of netizens, the next obvious question is - How can we change from byestanders to participants in this perfect storm coming our way?


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LINKS / REFERENCES

* Transcript - https://www.ted.com/talks/don_tapscott_how_the_blockchain_is_changing_money_and_business/transcript?language=en

* ABRA - transfering money freely and securely! - https://www.goabra.com/

* Imogen Heap - the first (?) Grammy awarded artist to sell her songs on Blockchain http://imogenheap.com/home.php?

* Vitalik Buterin - the founder of Etherium Bitcoin for Digital Contracts - https://en.wikipedia.org/wiki/Vitalik_Buterin

* Bitcoin Magazine - http://www.bitcoinmagazine.com/

Wednesday, July 06, 2016

Chasing out Yoursites123


I am constantly at odds with a virus that hijacks my browsers. It goes by the name "Yoursites123".

A few months back I had cleaned it out of Chrome and it worked just fine - until last week. Now the browser keeps hanging, forcing me to re-boot and employ that peculiar Chrome-special shortcut to get back all my tabs.

For a change, I switched back to Explorer and found that the earlier clean-up exercise had no impact on browsers other than Chrome. So when I got down, once again, to the step-by-step process for removing Yoursites123, a bigger problem surfaced - there were other bugs lurking in the dark corners.

Like the soot-balls in a Miyazaki movie, these turned up when I cast the following spell on the command-line:


The appearance of strange IP addresses below "localhost" is supposed to indicate that my PC has been hacked. And these three three fellows certainly look strange and suspicious.

127.0.0.1       down.baidu2016.com
127.0.0.1       123.sogou.com
127.0.0.1       www.czzsyzgm.com

What are these bugs doings in my machine? How do I get rid of them?

So far, all the online help available points you to some fancy sofware, which may again contain other new viruses. How do I figure the difference between online frauds and the do-gooders?

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LINKS

* Command Line reference - https://technet.microsoft.com/en-us/library/bb490890.aspx
* Removing Sougou - http://easyviruskilling.com/how-can-i-remove-123-sogou-com-virus-123-sogou-com-removal-guide/
* Removing down.baidu2016.com -- http://greatis.com/blog/how-to-remove-malware/remove-down-baidu2016-com.htm
* http://www.fixingvirus.com/remove-www-czzsyzgm-comwww-czzsyzxl-com-threat-and-protect-your-os/

Wednesday, September 16, 2015

On Batteries


How do batteries work?

Until today my understanding had been confined to high-school lessons in physics: lead anodes, cathodes, and of charged electrons swimming through sulphuric acid.

Now an enquiry from a friend in Japan is beginning to improve my understanding of an essential device that has become so common place that we not only take it for granted but also miss out on the wide range of batteries in the market now.

Here is an interesting video produced by EngineerGuy - Bill Hammack, University of Illinois:



If you decide to move on from lead acid batteries, the videos take you tthrough other interesting stuff like - the various uses of copper, Qweerty vs. Drovak keyboard layouts, magnetrons in microwaves and the connection between nutmeg and tantalum (!).

Coming back to batteries, they now come in serveral types -  AGM or dry, deep cycle or solar batteries. Unlike automotive batteries which are designed to give out a big burst of energy to start the engine, the AGM/Deep Cycle/Solar batteries are designed to discharge over a long period of time.

This is quite useful when you want to have, say, a streetlight running on solar panels. The panels absorb energy during the day, and keep the roads lit up all night on a single charge.

What if the such energy could be stored to run power-hungry equipment like freezers, microwaves and flatscreens? How would that work?

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USEFUL LINKS

- AGM (Absorbed Glass Mat) battery technology - http://www.solar-electric.com/agm-battery-technology.html/
- Running a microwave on a 12V battery - https://www.youtube.com/watch?v=WeY4qE2afvU
- Winiversal Inverter - https://www.youtube.com/watch?v=1ZhrqvYBqCE

* Power Inverter FAQ - https://www.donrowe.com/power-inverter-faq-a/258.htm
- AMPS X 120 (AC voltage) = WATTS -- This formula yields a close approximation of the continuous load of the appliance
- WATTS X 2 = Starting Load
- Induction motors such as air conditioners, refrigerators, freezers and pumps may have a start up surge of 3 to 7 times the continuous rating.
- The auxiliary battery should be connected to the alternator through an isolator module to prevent the inverter from discharging the engine start battery when the engine is off.

Thursday, September 10, 2015

Murthy Vs. Rao

Is there one invention from India that has become a household name in the globe? 
Is there one technology that has transformed the productivity of global corporations? 
Is there one idea that has led to an earth-shaking invention to delight global citizens?

These were some of the questions posed by Narayana Murthy at an IISc convocation ceremony in July 2015. As expected, it provoked loud yelps of protest from India's scientific community, including the big daddy of them all, Prof. CNR Rao, who countered it by just tossing the question back to Murthy - What has the industry contributed to S&T in India?

CNRR's rhetorical response does not, of course, answer any of the questions posed by Murthy. So a one can come to the concusion that the short answer to NM's questions is "Sorry, none at all."

Perhaps a part of the answer to Murthy's questions lies in the way scientists like CNRR are reacting to his convocation speech. A touchiness that comes from being insecure, a misplaced sense of self-importance, and an attitude that would do the proverbial ostritch very proud indeed!

Oddly enough, less than a week after Murthy's speech at IISc, CNRR stated (20 July) almost the same thing in different words. “The IISc. is characterised by very mediocre research", he said,  "mainly because they have a lot of facilities.” I guess the man who had a traffic circle outside IISc named after himself decided to change tack because he thought the institution was being criticised by an outsider who was a capitalist, and a bourgeois to boot.

Fortunately NM has refused to be drawn into a debate with CNRR. His simple response was, "He is a great scientist...So when he says something, all of us should listen to him with respect”.

Anybody who has read the full text of NMs speech would realize that his target audience was a whole generation of young scientists who who were going to seek greener pastures in the West. Even if  a few of them return home with one technology, one invention or one idea, it would still be a great outcome for India.


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LINKS

* Copy of the speech delivered by NM - http://scroll.in/article/741723/full-text-narayana-murthy-questions-the-contribution-of-iits-and-iisc-in-the-last-60-years
* CNR Rao's response - http://indianexpress.com/article/india/india-others/industry-contribution-to-science-pathetic-professor-c-n-r-rao/
* CNRR on IISc - http://www.thehindu.com/news/national/iits-iisc-are-not-the-best-in-the-world-says-cnr-rao/article2066308.ece


Saturday, August 22, 2015

Giga Hertz

1,000,000,000 vibrations per second. This is one Giga Hertz (GHz).

GHz is just a tiny sliver of the electromagnetic spectrum (EM) that surrounds us. Yet, it has become so indispensible in our lives that most of us barely give it a second thought.


Just consider this:

* Bluetooth Devices used in personal area networks (wireless earphones, speakers, etc.,) use the frequency range 2.4 to 2.4835 GHz. The protocol divides the band into 79 channels (each 1 MHz wide) and changes channels up to 1600 times per second!

* Micowave Ovens cooks your food and heats your coffee using high power magnetrons to transmit EM radiation in the 2.4 GHz band.

* Telecom Towers - Use the range 1 GHz to 300 GHz. Interfering with the high power transmission of these towers can be fatal, as proven by this case of Darwin Awards, titled "Christmans Roast".

I am yet to figure out how we managed to get such precise control over anything that transmits signals at amazingly high frequencies...


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LINKS

* Connectivity failure while using Bluetooth and USB-3 devices simultaneously - http://www.bluetoothandusb3.com/

* EM interference at 2.4 GHz - https://en.wikipedia.org/wiki/Electromagnetic_interference_at_2.4_GHz

* Instructables - http://www.instructables.com/id/Car-motorcycle-or-bicycle-wifi-alarm-rang-500m-10-/

Saturday, August 08, 2015

Science, Technology and Society


Last week there were two interesting events in New Delhi that gave us interesting perspectives on how Science and Technology is viewed in different societies, and across cultures.

The first was the screening of a documentary at IIC on G.N Ramachandran (aka GNR) the Indian scientist who discovered the triple-helix structure of Collagen, and the second, a talk at CPR by Prof. Sheila Jasanhoff from the Havard Kennedy School titled, "US-EU GM Crops Controversy: A Case for Epistemic Subsidiarity?".

The first one was fairly straightforward. The 30-minute documentary was on GNR, a scientist in newly independent India who sets up a frugal lab at Madras University, and using relatively basic equipment cracks a scientific problem that had eluded the likes of Linus Pauling and Francis Crick (of the DNA fame): the structure of Collagen, the most abundant protein in mammals.

The documentary desribes GNRs struggles to get adequate credit and recognition for this discovery, the attempts by British scientists to delay the publication of his findings in Nature, and of the fact that India had failed to recognise GNR adequately.

Prof. Jasanhoff's talk was on an altogether different plane. A scientist of Indian origin, she described her decision to focus on USA and EU as a "tactical decision" to avoid being straightjacketed as an India Scholar, and of her amazement at the way in which scientific data is interpreted in distinctly different ways across regulatory boundaries. The fact that there is a lack of consensus on this even amongst developed countries is described as the 'Paradox of Risk Governance'.

And what is Epistemic Subsidiarity? Perhaps one way of describing it is that knowledge and undestanding (epistemology) is best handled by devolving decisions on it to the lowest practical level (subsidiarity).

This framework is used to explain the big differences in the way USA and EU countries view Genetically Modified Organisms, leading up to the Asilomar Conference (1975) which drew up, for the first time, guidelines to ensure the safety of Recombinant DNA technology.

My biggest takeaway from both the events was the striking divergence in outlook of Indian scientists and of PIO/NRI scientists. The former has tied itself down in knots by basking in past glories, and creating an incentive system that stifles innovative thinking, while the latter has its sights focused on the future.

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LINKS:











Monday, June 29, 2015

An Offer to Work in India


How difficult is it for science & technology to thrive in India?

Everytime I see a news article or TV reporter gushing about the achievements of a scientist or entrepreneur of Indian origin, I am reminded of Prof. Venkatraman Ramakrishnan. In 2009, soon after he was awarded the Nobel Prize for Chemistry, Prof. Ramakrishnan declared, "Nobody has approached me about an offer to work in India. However, I can categorically state that if they did so, I would refuse immediately.”!

What explains this vehemance, this deep disenchantment?

Perhaps a part of the answer lies in the way we build and run our public-funded scientific institutions. Some of them are run like personal fiefdoms with no succession plan in sight ("after me the deluge!"), and in many others dedicated individuals find themselves embroiled in a constant battle with ted-tape.  

A couple of years ago, the official press release on the prestigious Marconi Prize  awarded to Prof. Paulraj, actually stated that he was driven out of India because "bureaucratic battles began to take their toll"... This was one scientist who returned to India, in 1986 from Stanford-U, and set up two institutions - CAIR and CDAC - before being hounded out. So he just went back to USA and went on to create the MIMO standard which is at the heart of 4G mobile technology we all use today.

Our short-sightedness was also highlighted recently in a widely circulated blogpost by Dheeraj Sanghi. Having been a member of numerous selection committee's, he describes how "Participating in...committee meetings can be very depressing as they expose this myth about India being the largest producer of scientific manpower."

Add to this the daily tussle we witness between the IITs/IIMs and the hon'ble Cabinet Minister for Human Resources Development, and the disheartening picture is all too complete.


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LINKS / REFERENCES

* (12 May 2015) - Dheeraj Sanghi - The Quality of Faculty -- http://dsanghi.blogspot.in/2015/05/the-quality-of-faculty.html

* (Firstpost, 2014): R. Jagannnathan - http://www.firstpost.com/india/nadella-as-microsoft-ceo-a-slap-in-the-face-for-indian-system-1374951.html
- We need to ask ourselves: why does our system kill future heroes, while the US helps raise even ordinary Indians to iconic levels
- The short point: our system is designed to keep people out, not get them in. The true value of an IIT or IIM is not the intellectual capital they produce, but their filtering expertise

* (Hindu, 2009) - Nobel Laureate bemused by deluge of goodwill -- http://www.thehindu.com/sci-tech/nobel-laureate-bemused-by-deluge-of-goodwill/article33379.ece


Monday, March 30, 2015

The Power of QA

How far will you go to buy a quality product?

According to the Economist, Chinese tourists are flying in droves to markets in Tokyo to purchase... toilet seats!

On the face of it this may seem a trivial or even whimsical thing to buy. But to those who have used to this piece of working art, it is difficult to see the regular plastic and ceramic contraptions as anything but retrograde.

However the point of interest is not the art or electronics but the fact that many of the seats the Chinese buy from Akihabara and carry back home, actually carry the label "Made in China".

Aparently, many Chinese consumers do not trust the reliability of such items sold at home—and refuse to pay the often higher prices charged for export-standard goods. Prime minister, Li Keqiang, has told Chinese firms to raise the quality of their own seats. “At least that could save consumers the price of a plane ticket,” he said.

Saving plane tickets is besides the point. It took a Chinese reader to hit the nail in the head:
I bought many stuffs in Japan even it says Made In China, but nothing in China itself because I know if the Chinese want to sell their stuffs in Japan, they must go through the rigorous Japanese quality assurance procedure, whereas there is none in China.
How do companies, and countries, acquire a reputation for accepting and delivering nothing less than the highest possible quality?

The Japanese embraced the ideas of an American guru, Edward Deming, to pull itself out of the morass of exporting poor quality umbrella's, matchboxes and textiles.

In India it appears that many outward looking, export-oriented companies have grasped the importance of perception, and understood the power of QA. There are also exceptional organisations like Aravind Eye Care and Narayana Health/Hrudayalaya that have blended high quality with affordability and public access.

What will it take for this idea to seem through our government and the vast network of institutions it controls?

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LINKS:

* http://www.economist.com/news/china/21647299-rush-buy-japanese-toilet-seats-prompts-soul-searching-china-race-bottom

Saturday, February 21, 2015

Swiss Dance


Wish I could understand modern dance.

The title of the performance we attended today was - "Re-mapping the Body - hear the movement / see the music", presented by Compagnie Linga, Switzerland, at the FICCI Auditorium. The work was supposed to make use of the 'dominant role of science and technology as adjuncts to the human body'.

The stage setting was quite dramatic. Placed on at centre of were half-a-dozen devices that looked liked pagers with their LEDs blinking. The show started in a rather un-Swiss way -- 15 minutes late -- with sound effects that seemed almost completely out of sync with the movements on stage.

At first we got the impression that the LED devices were movement sensors linked to sound system. This impressed gathered weight when the dancers were seen adjusting the settings carefully from time to time. The ticket had also claimed that the music was to be created entirely by the movements of the dancers. However the sounds seem to emanate from another altogether disjointed universe...

The dancers themselves were superb - each of them was amazingly lithe and agile. Despite the scratchy sound system and the squeaking chairs of FICCI auditorium, they managed to leave a lasting impression.

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LINKS -

http://www.linga.ch/en/home.php

Saturday, September 13, 2014

Bionic Limbs


The 'Jaipur Foot' looks so far away...
An amazing video on the latest bionic limbs -

Friday, September 12, 2014

Remembering Borlaugh

Last year, India set a new record in wheat production -- 95.85 million tonnes. This took the total food-grain production in the country to 264.38 million tonnes - another record in itself. To put the figures in perspective, consider a simple fact: At the time of independence we produced just 6 million tonnes of wheat.

All this we can trace back to the vision of one man - Norman Borlaugh.

As a young American plant pathologist he went to Mexico in 1944 to help fight hunger. Fifteen years of research in classical, selective breeding led him a dwarf variety of wheat which not only resisted rust, but also had a new plant gene that made them shorter with sturdier stalks which were able to withstand the weight of more abundantly grained wheat ears. His efforts resulted in a six-fold increase in Mexican wheat production.

The Indian government invited Borlaugh in 1966, at a time when the country had been reduced to a basket-case by successive droughts. He came in with a sackful of Mexican  wheat seeds. The rest, as they say, is history -- and the Green Revolution.

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REFERENCES & LINKS

* Tribute - http://www.business-standard.com/article/economy-policy/tribute-to-a-saint-who-did-miracle-with-wheat-114091200028_1.html
*Gene Revolution - the Antecedents - http://www.business-standard.com/article/opinion/shreekant-sambrani-gene-revolution-the-antecedents-113012200098_1.html

Tuesday, August 19, 2014

Plantibodies


Drugs based on antibodies have been in use for a long time now. So far, almost all these antibody-based drugs have been derived from animal sources -- usually mammalian cells from hamsters -- and then grown in large stainless steel vats. US-FDA has approved around 30 such drugs, including blockbuster cancer therapies such as Avastin and Rituxan (Roche).

The ongoing Ebola epidemic has brought into focus antibodies derived from plants (aka Plantibodies!). In the absence of any credible therapies, Mapp Pharmaceuticals (San Diego, USA) has been permitted to produce experimental 'Plantibodies' to treat two infected medical workers. Despite lower costs of plant-based production (~1/10th!) not many companies are into this area. The only such FDA approved drug is Elelyso, an enzyme produced from genetically engineered carrots, manufactured by Israel's Protalix Biotherapies, and marketed by Pfizer.

Which are the ~30 animal-derived drugs currently in the market? Why is it that major pharma companies are shying away from plant-based production lines that is supposed to be cheaper?

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REFERENCES /LINKS

* Plantibodies (Reuters, 18Aug14) --  http://www.reuters.com/article/2014/08/17/us-health-ebola-plants-analysis-idUSKBN0GH0DU20140817

* Ebola puts focus on drugs made in Tobacco plants -- http://www.jamaicaobserver.com/latestnews/Ebola-puts-focus-on-drugs-made-in-tobacco-plants

Thursday, July 31, 2014

Hello Finland!



How did Finland become home to Nokia?

On the face of it seems like an unlikely picture - a frigid, Nordic country as large as Thailand or Rajasthan state, with a population less than a third of Delhi's, it has managed to build an amazing manufacturing industry, centered on sophisticated equipment.

In a recent article, Ricardo Hausman, points out that the Finns started out quite logically by building on their biggest strength - its forests. So it was hardly surprising that a country with the highest forest-cover (75%) in Europe, would have a stong lumbering industry.

Yet, it went much, much beyond timber-based industries. It take good tools to bring down the huge trees, so they make excellent cutting machines; It is easier to transport paper than wood, so they have an advanced paper manufacturing industry.

A snowbound country with a population density of just 16/sqkm can be tough, so they built a good transportation, and a wireless communication industry.

How many other countries have transformed their weaknesses into strengths?

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REFERENCES:

* Ricardo Hausmann - http://www.project-syndicate.org/commentary/ricardo-hausmann-advises-poor-countries-not-to-focus-solely-on-adding-value-to-natural-resource-exports

* Trade in Finland - Imports & Exports - http://atlas.media.mit.edu/profile/country/fin/

* Examining Benefication - http://ricardohausmann.com/?p=878

* Forest Cover in Finland - the highest in Europe -- http://www.forest.fi/smyforest/foresteng.nsf/allbyid/BE3C5576C911F822C2256F3100418AFD?Opendocument

Sunday, June 01, 2014

Behind the Optic Fibre Networks

A hot summer afternoon in New Delhi. Next to a roadside manhole sit three youngsters under a rainbow colored umbrella. Clouds of dust swirling around them as they worked on dozens of strands of optic-fiber, each almost as thin as human hair.

Sweaty hand were deftly picking the strands one by one. They would be clipped using a small machine, wiped with a piece of tissue paper and then inserted into another unusual piece of equipment. Readings were being taken on a screen and then the process would start all over again with the next slender fiber.

The workers were apparently from Tata Telecom. They were just checking on a customer complaint on slow internet speeds. The equipment had come from "Fujikura" - 'Fuji's warehouse'. 

Fujiwara's equipment had customer-focus written all over it. Here was a semi-literate worker working in a dusty ditch in Delhi, using a sturdy piece of equipment made a company located 6000km away in Japan.

The wonders of technology -- and human ingenuity!

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REFERENCES & LINKS

* Fujikura Fusion Splicer -- http://www.fujikura.com/solutions/fusionsplicer/



Friday, May 09, 2014

Eyeing Botox

Clostridium botulinum (Image source: Wikipedia)

In 1895 a Belgian bacteriologist named Ermengem took a close look at a piece of rotten ham that had poisoned thirty-four people.

Under the microscope, Ermengem discovered a bacteria that would become the center of attention for military strategists, doctors, cosmetic surgeons, and foodies: Clostridium botulinum.

C. botulinum is an anaerobic spore-forming Gram positive bacteria which produces Botulinum neurotoxin (BoNT) - one of the world's most lethal biological weapon agents. One single gram of BoNT can kill 14,285 people (ingested), 1.25m people (inhaled), or 8.3 million people (injected). Amazingly, this very same toxin is now being used to cure vision disorders like Strabismus (squint eyes), amblyopia (lazy eyes), and for the removal of facial wrinkles (botox)!

How on earth did people discover that the most lethal neuro-toxin in the world can cure eye problems and make ladies look prettier??

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LINKS / REFERENCES:

- Botulinum Toxin Type-A (BXTA) - First Indian manufacturer (2007) - Bio-Med, Ghaziabad - brandname "BotoGenie" - http://www.biomed.co.in/aboutus.html
- Allergan Inc., USA - http://www.allergan.com/index.htm
- Coleman & Zilinskas (2010): FAKE BOTOX, REAL THREAT, Scientific American, June 2010 -- http://www.fakebotoxrealthreat.com/sitebuildercontent/sitebuilderfiles/sciam-botox-june2010.pdf
- NIH / NCBI: BIOWEAPON & MAGIC DRUG --- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028942/
-Talreja, Vishaka (2007): CHINESE BOTOX WON'T LET YOU LOOK YOUNG, TOI, 28Oct 2007 -- url -- http://articles.economictimes.indiatimes.com/2007-10-28/news/28481698_1_botox-treatment-botox-shot-chinese-botox
- A 100 unit Botox vial is priced at Rs 16,650. On the other hand the Chinese botox is available at a price 40% less than AllergAn's Botox.
- Anti-wrinke procedure costs Rs. 15,000 to Rs. 20,000
- 25,000 non-surgical Botox procedures in 2007 --- In USA there were 3 million such cosmetic procedures in 2006

Saturday, January 18, 2014

Battle of Clones


Yesterday, Biocon India launched a 'new', cheaper breast cancer drug called CANMab

In India, breast cancer is the second-most common form of cancer after cervical cancer with 150,000 patients being diagnosed every year. The new drug, CANMAb, is priced about 25% lower than Roche's Herceptin.

For all practical purposes, this seems to be a copycat drug. Like Heceptin, CANMAb too disrupts HER2 protein production and is being marketed as a 'Biosimilar' to a monoclonal antibody called Transtuzumab.

So what does this mean in plain English?

An antibody is a "Y" shaped protein used by our body to identify and kill intruders like bacteria and viruses. Like matching pieces of a jigsaw puzzle, a part of the Y-shaped protein identifies and 'locks' on to a unique part of a foreign target (called antigen). An intruder thus marked can then be destroyed by the immune system. Monoclonal antibodies are produced by identical immune cells and are exact replica's (clones) of the parent cell.

Biosimilars are substances derived from a living organism by techniques that use recombinant-DNA or controlled gene expression methods.

So Biocon India has essentially found a better, commercially more competitive method of producing monoclonal antibodies (MAb's), to take bite of the Swiss MNCs lobal market share ($6.4b globally and $21m in India), for an existing anti-cancer drug.

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LINKS & REFERENCES

Heceptin from Roche - http://www.herceptin.com/

Biocon Press Release - http://www.biocon.com/docs/PR_Biocon_CANMAb_18Jan2014.pdf?subLink=news&Fileid=467

http://en.wikipedia.org/wiki/Antibodies
http://en.wikipedia.org/wiki/Monoclonal_antibodies