This is not a book I would ever pick on an impulse. The cover itself is quite intimidating - a confusing, colorful blob of tangled ribbons. On first glance it looks like a tome for the lab nerds, for those seeped in structural biology, the followers of specialized science journals, and certainly not the general reader.
I picked this book only because on the dark cover, I noticed blurps from three writers I admire - Siddharth Mukherjee, Richard Dawkins and Bill Bryson. The stock comment ' I could not put this book down' from one of them pointed towards the possibility the book could be read - and understood - by folks like me, those who are not specialists but merely curious.
I was not at all disappointed. The author,Venki Ramakrishnan is the 2009 winner of the Nobel Prize in Chemistry, and his book, "Gene Machine" is a personal story of a physicist turned biologist who helped decipher the secrets of the Ribosome. Even if the topic sounds esoteric, the book is a down-to-earth narrative of a boy from Baroda who made it big.
Yet it is not the typical story of a south Indian vegetarian in USA. You get the impression of a adventurous, outgoing guy riding a series of lucky breaks. Perhaps the first of these came through a HoD at Baroda-U who got a letter from Ohio University seeking prospective students. Nineteen year old Venki is then offered a graduate scholarship without the usual GRE scores. He lands up in the America in the midst of the anti-war protests of 1971, and immediately after graduation, gets married to Vera Rosenberry, a talented illustrator of children's books, and a single mother.
In the initial chapters, Venki has a nice way of explaining his work with analogies. In the late 70s everybody knew that the ribosomes were responsible for protein synthesis, but nobody knew how -
"Imagine you are a Martian peering at the earth from above. You observe tiny objects on the surface that move mainly in straight lines, ocassionally turning at right angles...you could tell tht they consume hydrocarbons and emit carbon dioxide along with some pollutants and some heat. But you have absolutely no idea what these objects are, let alone how they work. Only by knowing the detailed construction of the object would you be able to see that it is made of hundreds of components that work together and that it has an engine connected to a crankshaft that make the wheels turn..."
Venki's search takes him from the university to his first job with the Oak Ridge National Lab in Tennessee and then to Brookhaven on the East Coast. Along the way, X-ray crystallography becomes the main tool for deciphering the structure of the various complicated components of the ribosome at the MRC Laboratory of Molecular Biology at Cambridge, UK.
The book also helps you catch a glimpse into the petty politics of those engaged in cutting edge science, of the walled garden that is open only to those from 'elite' institutions, and the manner in which the race for a Nobel Prize brings out the worst in many scientists.
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LINKS
Good Reads - Gene Machine - https://www.goodreads.com/book/show/39088590-gene-machine
