Showing posts with label drugs. Show all posts
Showing posts with label drugs. Show all posts

Monday, August 15, 2022

A Calculus of Crystals


The word "calculus", I discovered last month, has two meanings. The first is of course what we learn at school - a branch of mathematics that deals with variable quantities. The second one is common only in the world of pathology - "a stone-like concretion of minerals and salts found in ducts or hollow organs of the body".

It is shards of the second calculus that we see in the picture above, the 'concretion' that caused me much pain and discomfort last month. It was apparently a set of two minerals attached to each other, calcium oxalate and uric acid, one smooth and layered while the other one with its typical radial spikes. 

Whatever be its composition and size, one first-hand lesson was that the degree of pain and discomfort depends primarily on where the stone is lodged. Mine was 6.4mm wide, and stuck at a bend on the ureter, just before it empties into the urinary bladder.

This was not a recent development. Call it carelessness or apathy but I had been carrying this one in my system for at least the past 15 years, and it used to show up with clockwork regularity during the annual medical check-ups. The radiologist would stop at a particular point on my belly and say, "There seems to be an obstruction here...do you feel any pain?...No? Well, then, drink lots of water, and maybe it will get flushed out on its own." 

Years rolled by. I started every morning with a few glasses of water, I continued with my regular distance-running, trekking and traveling. At some point the annual check-ups ceased, and I all but forgot about the the radiologist's word of caution...until last month.

On a hot, humid July afternoon, I developed a niggling pain under my left ribs. Initially I assumed it was due to a particularly heavy lunch I had that weekend - rajma-rice followed by a double helping of ice-cream. I thought it would clear up on its own but the pain just doubled up, even after a bout of vomiting.

For the next few days, there was no let up on the pain, just the intensity varied during the day. Sometimes dull and deep, then sharp and persistent, there was no posture that eased it - sitting, walking or lying down. Even taking a deep breath seemed to take some effort; the elastic on pyjamas hurt, and a complete loss of appetite meant that that I was consuming only liquids.

At a nearby hospital the GP too read the symptoms wrong - it was misdiagnosed it as acute Gastritis. When three days of medication did not provide any relief from the sharp, persistent pain that kept me awake all night, an ultrasound test gave the first clue that the doctor was trying to solve the wrong problem. The stomach was perfectly fine but there was a significant swelling of the left kidney - "Left distal uretic calculus with moderate hydroureteronephrosis, and mild perinehpritic soft tissue stranding"

Translated from doctor-ese this simply meant that a stone in my left ureter had blocked the plumbing.  The old 'obstruction' had travelled down the ureter to a point where it had got completely stuck at a bend. Fluid trapped in my kidney had not only inflamed it but the tissues had also started getting damage. Something had to be done immediately to remove the blockage, before the rot spread into other complications.

I was actually quite relieved to hear this. It is a blessing to have an 'ordinary' problem, one that has a handy acronym, KSD (kidney stone disease), and something that affects 12 percent of the population. This also meant that there were SoPs for dealing with this in almost every hospital with minimum of hassles from the health insurance companies. So the course of action was also quite straightforward  - find a suitable hospital, and get the stone out ASAP.

We zeroed in on a hospital recommended by a friend, one that had an unusual name for an institution based in Delhi - Tirupati Stone Centre (TSC). Even though it was located at one of the busiest crossings I have seen in East Delhi (Karkadi Mor, Gagan Vihar), the hospital itself was an island of quiet efficiency, staffed by sensitive folks and a set of supremely competent nurses from Kerala.

At TSC, Dr. Ajay Agarwal took a look at the ultrasound and CT scans and concluded that immediate action was required. The very next day afternoon I was on an operation table for a spinal anaesthesia followed by a procedure that blasted my kidney stones with a laser-beam, and propped up my urethra with a temporary stent.  The procedure took about 40 minutes but it took about four hours for the anaesthesia to wear off, and for the gradual return of sensation to my limbs - little toes, ankles, knees, hips, and then the big toes!

I feel perfectly fine now - only the stent needs to be removed later this month. As in the case of high-school mathematics, it is quite a relief to be spared of the pain and discomfort that emerges from an unresolved calculus problem!

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For those who may find themselves among the 12 percent of the population facing the same ailment, here is a checklist of precautions, tests and drugs that you too may encounter - 

Precautions:
  • Get a second opinion on the initial diagnosis - tests are important. In my case it was the ultrasound that led us to discover that the problem was with the kidney, not the stomach.
  • At private hospitals that are run like Yatharth Hospital Noida, doctors can get their diagnosis wrong
  • Hospital admin & accounting rules are such that the emergency services the staff is very hesitant about using their own stock of drugs  and disposables. Even in a critical situation be prepared to see your 'attendant' being sent off to buy injections and syringes!
  • Telemedicine may be the in thing but insurance companies want prescriptions on paper! On a Sunday the doctor sent us a message on WhatsApp recommending a CT scan but this became s sticking point for the mediclaim company (NIAC) and caused considerable delay in approvals.

Tests: 

- Blood tests
- Urine tests + culture
- Ultra sound
- Kidney function test (KFT)
- Liver function test (LFT)
- CT - KUB - kidney, ureter and bladder


Medicines:

For Gastritis (mis-diagnosis at Yatharth Hospital)

- Pan 40 (Alkem) - Pantoprazole Gastro-resistant tabs: It's used for heartburn, acid reflux and gastro-oesophageal reflux disease (GORD)...proton pump inhibitor (PPI), reduces acid in stomach --- https://www.1mg.com/generics/pantoprazole-210457
- Lesuride  (Sun pharma) - Levosulpiride tabs: atypical antipsychotic. It works by increasing the release of acetylcholine (a chemical messenger). This increases the movement of stomach and intestines, and prevents reflux (acid going up to the food pipe) --- https://www.1mg.com/generics/levosulpiride-210137
- Drotin DS (Walter-Bushell) - Drotaverine Hy: an antispasmodic medicine which relaxes the muscle gives and effective relief from pain, spasm or twitches of the smooth muscles in the stomach and heart --- https://www.practo.com/medicine-info/drotin-80-mg-tablet-20225

For Kidney inflammation (on WA)

- Ceftum 500 (GSK) - Cefuroxime Axetil - an antibiotic medicine used to treat bacterial infections --- https://www.1mg.com/drugs/ceftum-500mg-tablet-58680
- Enzoflam (Alkem) - Paracetamol Diclofenac: pain relief - Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and Paracetamol is an antipyretic (fever reducer) --- https://www.1mg.com/drugs/enzoflam-tablet-64343


Post-Op:

- Exfaro 300 (Intas) - Faropenem Sodium ER: Anti-bacterial...can cause diarrhea as a side-effect
- Tab A to Z (Alkem) - multi-vitamin capsules
- Rablet-D (Lupin) - Rabeprazol sodium: Proton pump inhibitor (PPI) used to treat stomach problems (acid redux, ulcers, etc) by decreasing the amount of acid  --- https://www.webmd.com/drugs/2/drug-17504/rabeprazole-oral/details
- Roliflo 4mg (Sun pharma) - Tamsulosin + Tolterodine: to treat benign prostatic hyperplasia...to relax the muscles of the bladder and prostate gland...to control urge to urinate https://www.1mg.com/drugs/roliflo-od-4-capsule-er-123224
- Drolgan for SOS only (Ipca labs) - Drotaverine (80mg) + Aceclofenac (100mg): to reduce abdominal pain and bloating...relaxing muscles of stomach and gut by blocking certain chemical messengers --- https://www.1mg.com/drugs/drolgan-tablet-64223
- Alkastone syrup (Corona remedies) - Potassium Citrate + Magnesium Citrate + Vitamin B6 (Pyridoxine): makes urine less acidic, gets rid of uric acid, dissolves stones...B6 prevents stone formation --- https://www.1mg.com/drugs/alkashot-b6-oral-solution-delicious-pineapple-sugar-free-636244
- Amiject 500 (Alkem labs) - Amikacin sulphate injection recco by Nurse Jasmine @Tirupati: class of drugs known as aminoflycoside antibiotic...stops growth of bacteria --- https://www.webmd.com/drugs/2/drug-3889/amikacin-injection/details 

Prior to Removal of Stent:

- Niftran 100mg (Swiss Garnier Biotech India PL) - anti-bacterial UTI, once daily until removal of stent two weeks later - https://www.1mg.com/drugs/niftran-100mg-capsule-150942

 

Thursday, August 27, 2020

Huitzilopochtli & Narcos

It is fascinating to see modern problems being framed through the lens of mythology. In the tele-series "Narcos" a drug lord invokes the patron god of the Mexica tribe to explain the war of succession in his smuggling cartel, "Even Huitzilopochtli had to kill his brothers to sustain the sun, and to save the world from darkness".

Much has been written about this tele-series but I found the first part (on Escobar and the Medellin Cartel) a lot better than the sequels. The story moves a good pace, and its fascinating to see how a petty smuggler of washing-machines takes to smuggling cocaine under trucks laden with Peruvian potatoes, and how it destroys country after country. 

The first part is also high on nuance. Not all drug-lords sell their souls for easy-money - some of them see it as a tool to improve lives of impoverished rural communities; US agents are not one insensitive, evil monolith - there are differences in priorities and objectives of DEA, CIA and the State Department - and each of them has no qualms about undercutting the other to claim that all-important visibility and increase in annual budget. Human relationships also matter - Escobar was ruthless but he was also gentle and loyal to his family, and his own father pitied and loathed him for all his bravado and brutality.

I don't know to what extent this series was short on location, in Columbia or Mexico it is nice to see so many different houses, surrounded by lush gardens, bathed in sunlight.

Neither did I know the difference between the drugs that are extracted from three different plant -  cannabis, coca and poppy.  Now it is clear from the Cannabis you get marijuana, hashish and hashish oil; from Poppy you get morphine, codeine, heroin and oxycodone, and finally, from Coca, you get cocaine.

While working in Afghanistan, I had learnt how poppy fits neatly into the socio-economic gaps of demands and supply. The crop thrives in the most drought prone areas, gives the farmers some form of dependable revenue to feed their families, but it also fuels the internecine wars with a good chunk of 'export' earnings going for buying weapons. And yet, the money made by the Taliban on afghan poppy is not a patch on the empires built by the South American drug cartels. A conservative estimate is that USD 100 billion worth of drugs flows into USA and just Columbia earns about USD 30 billion from its illegal exports. 

As the Narcos series moves from Escobar to the exploits of DEA agent Kiki Camarera, his brutal torture, killing and subsequent retribution; the rise of the Cali Cartel and the rise of the Mexican cartels, all the way to El Chapo, you can clearly see a drop in quality. Story-lines stretch, actors appear wooden, dialogues stilted and cliched. I had to stop watching after two episodes of El Chapo. My patience and capacity for binge-watching had run out - thus far and no further!

.............................


* Illegal Drug Trade - https://en.wikipedia.org/wiki/Illegal_drug_trade

* DEA Museum - Coca, Cannabis and Poppy - https://www.deamuseum.org 

* https://en.wikipedia.org/wiki/Hu%C4%ABtzil%C5%8Dp%C5%8Dchtli

* Narcos Mexico -https://en.wikipedia.org/wiki/Narcos:_Mexico

Saturday, April 16, 2016

Delhi Belly +


Last week, I had the most unusual of Delhi Bellies.

As far as I can remember, this is the first time I spent more than 24 hours with symptoms that went way beyond the usual stomach upset. Even after I thought my body had expelled the last traces of a mutton biryani, I continued to double up with a stabbing pain on my sides, moving restlessly from the bed to the floor, to violent bouts of vomiting, as though the body was trying to yank out a knife that had got stuck deep inside my empty intestines.

Finally when we go around to seeing a doctor, this seemed to be so mundane, so ordinary a case that I was out in a few minutes with this Rx in hand:
  •  Esoga RD (Abott) - Enteric coated Rabeprazole Sodium & Domperidone SR Capsules (BB 1-0-0 before breakfast) - ₹103 for strip of 10
  • Taxim-O 200 (Alkem House) - Cefixime tablets IP (1-0-1 after meals) - ₹130/strip
  • Drotin (Martin & Harris) - Drotaverine Hydrochloride (SOS) -
  • Floristore (Zyventus) - Probiotic culture concentrate not less than 2.5B CFU capsules (1-0-1 about 30 minutes after meals)

The relief was almost immediate. That little knife in my intestines seemed to melt away, the vomiting ceased and I was up and about with a few hours.

How did this little miracle come about? What did the pills actually do inside my body?



Domperidone, seems to have acted on the dopamine receptors and stopped me from vomiting while the Rabeprazole Sodium - a proton pump inhibitor (PPI) - reduce the levels of acid in my stomach so that the real hero, an antibiotic named cephalosporin (Taxim / Cefixime) busted the bacteria (most likely Helicobacter pylori) which was the root-cause of the stomach infection.

On the sidelines, Drotaverine Hydrocholoride (Drotin) acting as an anti-spasmodic, helping with the vomit-control mechanisms. It is interesting to know that the same drug is used to 'enhance cervical dilation during childbirth'!

Th last set of capsules (Floristore) contained probiotic cultures to restore the ecosystem of friendly bacteria in my stomach that would have got destroyed by the antibiotics.

Medical science seems to have got the entire game figured out. The experience leaves me wondering how people coped with food poisoning before the advent of antibiotics...and with rising levels of antimicrobial resistance (AMR), who will we cope with bacteria that have learnt how to deal with broad-spectrum antibiotics like cephalosporins?

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REFERENCES & LINKS

http://www.rxlist.com/aciphex-side-effects-drug-center.htm

https://www.nlm.nih.gov/medlineplus/druginfo/meds/a690007.html




Saturday, February 20, 2016

How Did We Know?


Conciousness is a strange thing.

On one hand it is easy to grasp that there could be a world beyond the reach of our five sense organs, but on the other it is not often that you come across proof that hits you like a ton of bricks. In books like "Autobiography of a Yogi" and "Apprentice to a Himalayan Master", there are numerous illustrations of paranormal perceptions, of yogi's being aware of events taking place thousands of miles away, of fantastic realms and parallel universes, but every now and then, you are confronted with facts that are difficult to brush aside.

First, the questions raised by Kurshed Batliwala:




  • How did the ancients know that the earth was round? (Varaha-avatar, "Bhu-gol")
  • Antares star (15th brightest) was called "Jeshtha" (the eldest, biggest) is actually 40,000 times larger than the sun, and one of the biggest celestial objects known to man. How did they know this 7000 years ago?
  • In the Great Bear constellation (Ursa Major), the tail has a bright star called Mizar which -- when seen through telescopes - turns out to be a  twin star. In ancient India, it was always called the Arundhati-Vashishta which actually goes around each other -- a kind of stellar tango. How did they figure this out?
  • Rust-proof Iron Pillars - (1) Qutub, Delhi (2) Kollur, Karnataka - been around for at least 2400 years...built to welcome Shankaracharya (?)
  • Extracting Zinc from ore. Melts at 997C, but vapourises at 1000C -- "Indians built an innovative up-side-down furnace to extract zinc...a process that was secret for 4000 years...first the Chinese stole it from us, then the British stole it from the Chinese". Process was patented by William Champion (1543) who made the first Zinc Distillery in England. 
  • (According to Wiki, Champion used a scaled-up process similar to that used at the Zawar mines in India where this process was available centuries before William Champion rediscovered it, since the 12th century AD)
  • Katapaya-dhi Sankhya in a sloka praising Krishna gives the value of Pi up to 30 decimal places! What was the point in encrypting Pi into a Sanskrit sloka?
  • Vasco-da-Gama's 'discovery of India' - in the Purtuguese journals,he was 'escorted' by a Gujarati trader who had ships 12x larger than Vasco's ships, and yet, in the European narratives, he is depicted as a mere 'guide'!


And then we have the questions raised by Graham Hancock in his controversial TED presentation:




  • Dimethyltryptamine (DMT) is a potent psychedelic drug. Usually it is smoked because in the stomach it gets broken down by an enzyme (monoamino-oxidase). However, the Indians in South America mix it with juice extracted from a vine which is a MAO inhibitor. How did the Indians know that out of the 150,000 vines available, this particular one had the MAO inhibitor?



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REFERENCES & LINKS

* BharathGyan -- http://www.bharathgyan.com/

* Khurshed Batliwala's videos -- https://www.youtube.com/watch?v=I9aR_xfm-gE

* Autobiography of a Yogi (Yogananada)

* Apprentice to a Himalayan Master (Sri M)

* Graham Hancock -- https://grahamhancock.com/ted-war-on-consciousness-hancock/