Showing posts with label S&T. Show all posts
Showing posts with label S&T. Show all posts

Tuesday, April 08, 2014

Guha on Import Dependence

"Almost all elected members of GRC are SSB prize winners...an entry into this club means that you have arrived"

In the world of Indian sci-tech GRC and SSB are acronyms even a novice would know. The former stands for Guha Research Conference set up in the name of B. C. Guha, and the latter, the Shanti Swarup Bhatnagar Prize.

This makes it all the more strange that a Google search on GRC would only get you a long list of Indian scientists who are proud to call themselves "elected members" without any publicly accessible information on how this club functions. There was no Wikipedia page on Guha Research Conference, until today.

According to Parthasarathi Banerjee, affiliation to GRC, "acts as the token, assuring easier access to prizes of several sorts."  The SSB Prize is one of them.

As far as institutions go, GRC presents an interesting case to all those who are curious to know why India's output is so sad when it comes to applied S&T. The organization is named after Prof. Bires Chandra Guha (1904-1962) who is referred to as the 'father of modern Indian biochemistry'.

Guha was, no doubt, a person of many interesting dimensions. He was a freedom fighter, an artist and a scientist who worked closely with many Nobel laureates in UK and USA. After independence, he returned to India and helps establish many a national institution like CFTRI, Mysore.

Way back in 1956, he made a sharp observation - "It is undesirable that practically all fine instruments of measurements should have to be imported. Biochemical researches in these days are greatly dependent on such instruments and biochemists in this country should make a special plea for the manufacture of these instruments".

Half-a-century later our labs continue to be helplessly dependent on foreign manufacturers for nearly all their equipment and reagents.

It would be interesting to know that the eminent members of GRC have been doing to solve this long-standing problem..


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LINKS

* Wiki on GRC  (created 7 April 2014) -- http://en.wikipedia.org/wiki/Guha_Research_Conference

* Biresh Chandra Guha: Father of Modern Biochemistry in India -- http://www.iisc.ernet.in/currsci/sep252004/823.pdf

http://books.google.co.in/books?id=dLT2PMgI7MsC&pg=PA231&lpg=PA231&dq=guha+GRC+india&source=bl&ots=m4w1gtdCe3&sig=u_wgXWGeeEzfG30l4tW4aOfLFNU&hl=en&sa=X&ei=s1JCU5ulGsWFrAeC3oDIDw&ved=0CEoQ6AEwBA#v=onepage&q=guha%20GRC%20india&f=false

Wednesday, March 26, 2014

CDRI & Drug Discovery in India


India is currently a world leader in the manufacture of generic drugs. These are generally off-patent medicines marketed under their original chemical name, without advertising.

Since these drugs are usually produced and sold in bulk, profit margins are wafer thin. The real meat in the pharmaceutical business lies in the branded block-buster drugs that have taken years to develop.

How many new drugs have been developed or discovered in India, since 1947?

According to the Central Drug Research Institute (CDRI, Lucknow), the answer is 16. Nearly 70% of these have been developed in CDRI itself.  They are --

  • Centchroman - world's first non-steroidal oral contraceptive  - marketed by Hindustan Latex Ltd under the trade name, Saheli and as Centron by Torrent Pharma.
  • Arteether: antimalarial, from the plant Artemisia annua. Marketed by Themis Chemicals Ltd. under the trade name E-Mal. 
  • Standardised Herbal Remedy (can this be called a drug?):  memory enhancer derived from the plant Bacopa monniera. Marketed as Memory Sure
  • Consap (spermicidal cream) derived from soapnut
  • Bulaquin, an antirelapse antimalarial, comparable to primaquine. Marketed by Nicholas Piramal as a combination therapy along with chloroquine under the trade name Aablaquin. 
  • Gugulipid, a hypolipidaemic, is a standardised fraction of the plant Commiphora mukul. Cipla is marketing it under the trade name Guglip.
  • Chandoniun Iodide - ??
  • Cent bufinodole - ??
  • Centpropazine (antidepressant) - ??
  • Centbucridine, a local anaesthetic mktd by Themis Chemicals Ltd. as Centoblok. 
  • Centimizon -??


The CDRI list seems to be in descending order to oblivion. The further you're down the list, the URLs too go wonky, linking you to completely unrelated pages.

In any case, the only one that remembered seeing at a medical store, was Saheli, and Memory Sure.

If this is what we get after spending public money for 64 years at CDRI?

Which are the other five drugs discovered in India? Do they - hopefully - fare better than CDRI's star-performers?

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LINKS
* "New drugs" from CDRI -- http://www.cdriindia.org/newdrugs.htm
* Centchroman / Saheli -- http://www.cdriindia.org/centchroman.htm
* (ToI, 18 Feb 2012) -- http://timesofindia.indiatimes.com/city/lucknow/CDRI-underlines-its-2011-progress-on-61st-annual-day/articleshow/11932436.cms